Targeting CD146 with anti-CD146 antibody AA98, in conjunction with an anti-TNF-alpha antibody specifically, showed promising results in mice. Their report is released in The American Journal of Pathology. Enhanced CD146 expression has been reported on endothelial cells in intestinal biopsies from individuals with inflammatory bowel disease. There have also been scientific observations that CD146 expression is connected with other inflammatory diseases such as rheumatoid arthritis, chronic renal failing, and diabetes.At the final end of 2014, BioMed Central and other publishers alerted the international Committee on Publication Ethics to new types of systematic attempts to manipulate journals’ peer-review procedures. According to a declaration published on COPE’s internet site in January 2015, these attempts to hijack the scholarly review system were evidently orchestrated by companies that 1st helped authors write or improve their scientific articles and marketed them favorable peer testimonials.4 BioMed Central conducted a thorough investigation of all their recently published content and identified 43 which were published based on reviews from fabricated reviewers.