Discussion Activated factor IX plays a central role in the extrinsic and intrinsic coagulation pathways; when the level of factor IX is low, there is excessive bleeding, and when the level is elevated, there is thrombophilia. As opposed to the identification of hundreds of mutations in the element IX gene that trigger deficient clotting activity ,15 the molecular basis of increased levels of factor IX is definitely unknown.6,16 The factor IX mutation reported here was connected with markedly increased activity of factor IX and with thrombosis in the proband.Three photos with the DTaP/HepB/IPV vaccine drive back all five diseases. Kids receiving DTaP vaccine would want at least six additional shots of IPV and HepB vaccine to obtain the same security. Vaccinations were more timely for children receiving the 5-in-1 mixture. On a list of eleven different recommended vaccines, the entire on-time vaccination rate was 66.3 % for children receiving the DTaP/HepB/IPV vaccine, in comparison to 60.8 % for all those receiving DTaP vaccine. By age two, children receiving the 5-in-1 vaccine had fewer days without all recommended vaccinations: about 30 days on average, in comparison to 70 days in the DTaP group.