The absence of a particular immunologic disorder led us to employ a positional cloning method of identify the patients’ underlying genetic defect. Genetic Linkage Analysis Evaluation of the SNP genotypes showed a region of ideal segregation on chromosome 9 , so long as Patient 1B1’s bout of candida infection was the consequence of a phenocopy. This locating was confirmed by genotyping four microsatellite markers, yielding a peak multipoint lod rating of 3.6 . There were 121 genes in the maximal linkage interval defined by the microsatellite markers D9S2157 and D9S1838 .Bacterial meningitis may appear for a true number of reasons. Often, it is the result of contamination by bacteria that reside in the nose and mouth already. The bacteria enter the blood and become lodged in the brain`s external covering, the meninges. Meningitis can also be due to the spread of contamination occurring close to the brain, such as from the ears or the sinuses. It is also an intermittent complication of brain, head, or neck medical procedures. The average age group for meningitis is 25 years, and meningitis affects equally men and women. For unclear reasons, African-Americans appear to develop meningitis more frequently than do folks of other races.