It will be the patient, in collaboration with his healthcare professional, who will ultimately need to weigh the sensitivity-specificity tradeoffs in combination with the uncertain organic history of the disease to determine whether additional evaluation with a prostate biopsy is appropriate,’ the authors conclude.. Precision of PSA screening for detecting prostate cancer A new study indicates there is absolutely no specific PSA value which has both high sensitivity and high specificity for monitoring healthy guys for prostate cancer, but instead there exists a continuum of prostate cancer risk at all ideals of PSA, according to a report in the July 6 issue of JAMA: The Journal of the American Medical Association. Probably the most common cancer screening actions in the United States may be the measurement of prostate-particular antigen amounts for the first detection of prostate cancer, according to background info in this article.Copyright 2009 Advisory Panel Kaiser and Company Family members Foundation. All rights reserved.. Gavin Giovannoni, M.B., B.Ch., Ph.D., Giancarlo Comi, M.D., Stuart Cook, M.D., Kottil Rammohan, M.D., Peter Rieckmann, M.D.D., D.M.Sc., Patrick Vermersch, M.D., Ph.D., Peter Chang, Ph.D., Anthony Hamlett, Ph.D., Bruno Musch, M.D., Ph.D., and Steven J. Greenberg, M.D. For the Clearness Study Group: A Placebo-Managed Trial of Oral Cladribine for Relapsing Multiple Sclerosis Multiple sclerosis is a chronic and debilitating autoimmune disorder of the central nervous system, in which B and T cells are thought to play a major pathophysiological function.1-3 Treatment benefits and disease modification can be acquired with the currently approved parenteral immunomodulatory and immunosuppressant therapies: interferon beta, glatiramer acetate, mitoxantrone, and natalizumab.