1 and two common complications in atrial fibrillation are stroke and heart failure.


Methods Study Protocol and Design A steering committee was in charge of the design, conduct, and reporting of the scholarly study. The Population Health Analysis Institute designed the scholarly research, gathered all data, adjudicated outcomes, and performed the analysis. Representatives of Bristol-Myers Sanofi-Aventis and Squibb, the study sponsors, were associates of the steering committee, however the sponsors acquired no direct function in the collection, evaluation, or interpretation of study data or in the composing of the manuscript. The members of the writing group had full usage of all data and acquired last responsibility for publication decisions. The process was accepted by the correct regulatory authorities and the ethics committee at each site.Furthermore, about one third of patients in our study got disease progression despite maximally intensive statin therapy. This obtaining suggests a possibly important role for novel agents designed to reduce LDL cholesterol levels, increase HDL cholesterol levels, or modify disease activity through other pathways. Certainly, a substantial residual risk of clinical occasions remains generally in most secondary-avoidance populations despite the make use of of the most effective current medical therapies, affirming the need for new antiatherosclerotic brokers. This scholarly study has important limitations. It had been not ethically feasible to measure disease progression in placebo-treated patients.